For people with cardiovascular disease: If you have a history of cardiovascular disease, you should only use febuxostat to treat your gout in two situations. When flying, never put it into a checked bag. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Talk to your doctor if you’re pregnant or planning to become pregnant. Allopurinol is used in the treatment of high uric acid levels associated with gout, kidney stones, and cancer treatment. Probenecid, taken as a pill. Febuxostat is used to lower uric acid levels in people with gout.Febuxostat works by reducing the amount of uric acid made by the body. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. If your symptoms or health problems do not get better or if they become worse, call your doctor. Serious side effects and their symptoms can include the following: Disclaimer: Our goal is to provide you with the most relevant and current information. Examples of drugs that can cause interactions with febuxostat are listed below. This information is not a substitute for medical advice. Your doctor will write the number of refills authorized on your prescription. A boxed warning alerts doctors and patients about drug effects that may be dangerous. The second is if you’ve tried allopurinol and it was not effective enough for you. To help prevent this, your doctor may prescribe NSAIDs, colchicine, or steroid tablets as well as allopurinol or febuxostat. Allopurinol may be better tolerated if taken with food. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. Don’t store this medication in moist or damp areas, such as bathrooms. Normal serum uric acid levels are normally achieved within one to three weeks. Febuxostat oral tablet can interact with other medications, vitamins, or herbs you may be taking. This can be harmful or prevent the drug from working well. All possible dosages and drug forms may not be included here. For children: This medication has not been studied in children. © 2005-2021 Healthline Media a Red Ventures Company. Call 911 or your local emergency services if your symptoms feel life-threatening or if you think you’re having a medical emergency. Febuxostat oral tablet is available as the brand-name drug Uloric. Medicines that interact with allopurinol may either decrease its effect, affect how long it works for, increase side effects, or have less of an effect when taken with allopurinol. Over time, your levels of uric acid should stay lower than 6 mg/dL. People administered allopurinol for high uric acid levels occurring as a result of cancer are at higher risk of developing kidney damage from allopurinol. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use allopurinol only for the indication prescribed. May interact with a number of different drugs including mercaptopurine and azathioprine (the dosage of these two drugs needs to be reduced to approximately one-third to one-fourth of their normal dosage). The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. You may need a lower dose of febuxostat. This means you may need to take it with other medications. Keep these considerations in mind if your doctor prescribes febuxostat for you. Other treatments (such as NSAIDs or colchicine) are usually prescribed to be taken during an acute gout attack. Gout is a type of arthritis that causes sudden and severe attacks of pain, but luckily, the right diet can ease its symptoms. View complete list of side effects. For this drug to work well, a certain amount needs to be in your body at all times. This information is not a substitute for medical advice. Copyright 1996-2021 Drugs.com. Febuxostat vs. allopurinol. The sensitivity and specificity of the clinical decision tools appear to be just as good as, if not better than, imaging without the added cost or risk. Febuxostat, taken as a pill. Allopurinol reduces the production of uric acid (a compound produced by the body associated with gout and kidney stones), by inhibiting an enzyme called xanthine oxidase. Revision date: March 19, 2020. sodium bicarbonate, febuxostat, Uloric, Zyloprim, probenecid, rasburicase, Krystexxa, pegloticase, Elitek, Aloprim. These issues include your: Uric acid results from a breakdown of substances called purines. This is considered a serious event and allopurinol should be discontinued immediately and urgent medical advice sought. Your dosage will depend on: Febuxostat has not been studied in children. It can make you drowsy. Single-center trials have shown that urate-lowering treatment with allopurinol or febuxostat could slow the progression of chronic kidney disease over a short follow-up period of 6 to 12 months. These drugs are often used to treat similar conditions. Examples of these drugs include: Taking febuxostat with certain drugs raises your risk of side effects from those drugs. The first is if you’re not able to take the gout drug allopurinol. If they’re more severe or don’t go away, talk to your doctor or pharmacist. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. When filling your prescription, be sure to call ahead to make sure your pharmacy carries it. Febuxostat is a prescription drug. Taking it again could be fatal (cause death). Examples of these drugs include: Disclaimer: Our goal is to provide you with the most relevant and current information. Your doctor or dietitian may tell you to limit the amount of these foods that you eat. If you experience these symptoms, call 911 or your local emergency services or go to the nearest emergency room. Speak to your doctor about how drug interactions should be managed. Many insurance companies require a prior authorization for this drug. Drugs such as allopurinol (Aloprim, Lopurin, Zyloprim) and febuxostat (Uloric) help limit the amount of uric acid your body makes. Healthcare professionals are advised to avoid treatment with febuxostat in patients with pre-existing major cardiovascular disease (e.g. Common medications that may interact with allopurinol include: Note that this list is not all-inclusive and includes only common medications that may interact with allopurinol. Symptoms can include: If you develop these symptoms, call 911 or your local emergency services or go to the nearest emergency room. In an average-sized adult or child above the age of 9, the half-life of caffeine is approximately 5 hours. Your doctor should monitor certain health issues while you take this drug. Do not take these drugs with febuxostat. It should not be used in children younger than 18 years. This may make it difficult for your doctor to tell how this drug is affecting your liver. Never try to catch up by taking two doses at once. Febuxostat oral tablet is a prescription medication used to treat hyperuricemia (high levels of uric acid) in adults with gout. Call your doctor right away if you have serious side effects. It helps decrease symptoms of … Do not drive or operate machinery if allopurinol makes you drowsy or impairs your judgment. Xanthine oxidase is an enzyme that helps your body make uric acid from the substance xanthine. Allopurinol is used to prevent future attacks of gout by reducing the production of uric acid in the body. For people with liver disease: This drug has not been studied in people with severe liver disease. Taking febuxostat places you at a much greater risk of cardiovascular death than taking allopurinol. Be sure to avoid doing this when the weather is very hot or very cold. This could result in dangerous side effects. Here's what you need to know about the benefits, side…, The risk of getting COVID-19 from food or food packaging is low. If a rash occurs while taking allopurinol, immediate discontinuation of allopurinol is required and urgent medical advice should be sought. May precipitate gout attacks during the early stages of administration, even when uric acid levels are normal. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. sudden numbness or weakness in your face, arms, or legs, trouble seeing out of one or both of your eyes, sudden trouble walking, dizziness, or loss of balance or coordination, jaundice (yellowing of your skin or the whites of your eyes), swelling in the upper right part of your abdomen. We comply with the HONcode standard for trustworthy health information -, Calcium Oxalate Calculi with Hyperuricosuria, https://www.drugs.com/ppa/allopurinol.html. You may need blood tests done to monitor your treatment while you take this drug. Call your doctor right away if you have worsening symptoms of gout, or if your gout symptoms don’t get better after six months of treatment with febuxostat. If you forget a dose of allopurinol, you do not need to double up the next dose. Select one or more newsletters to continue. Learn what medications are available to help keep your symptoms under…. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking. For pregnant women: Research is limited regarding the use of this drug in pregnant women. Learn why it occurs, what the symptoms are, and how to treat it. This drug may also cause liver function test results that aren’t accurate. So, as a precaution, it’s likely you’ll be prescribed a low-dose NSAID or colchicine to take on a daily basis for the first six months of starting febuxostat. Monitoring is necessary for people with pre-existing liver disease and an investigation into the functioning of the liver should be conducted if symptoms such as weight loss or itchy skin develop. Your symptoms of gout should also go away. Keep taking this medicine (allopurinol tablets) as you have been told by your doctor or other health care provider, even if you feel well. Pegloticase, given as an intravenous (in the vein) infusion. Medically reviewed by Carmen Fookes, BPharm. Data sources include IBM Watson Micromedex (updated 3 Mar 2021), Cerner Multum™ (updated 1 Mar 2021), ASHP (updated 3 Mar 2021) and others. Seek immediate medical advice if unexplained weight loss or itchiness develop while you are taking allopurinol. The dosage of allopurinol needs reducing in people with kidney disease and their renal function monitored at least during the early stages of therapy. Febuxostat is more likely to trigger gout attacks than allopurinol when you first start treatment. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have severe liver disease, talk to your doctor about whether this drug is right for you. It is not unusual to experience a gout attack in the first few weeks of allopurinol initiation. Febuxostat may interact with other medications, Important considerations for taking febuxostat, Hyperuricemia: Symptoms, Treatment, and More, Best Diet for Gout: What to Eat, What to Avoid. This article reviews the…, More than 8 million Americans have gout, a condition that causes painful inflammation in the joints. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. Some may be better suited for you than others. What to do if you miss a dose: Take your dose as soon as you remember. It comes only as a tablet you take by mouth. 12 About 0.5% to 2% of a caffeine dose is found excreted in urine, as it because it is heavily absorbed in the renal tubules. Healthline Media does not provide medical advice, diagnosis, or treatment. Some foods that contain purines include liver, dried beans and peas, and anchovies. May also be used to treat recurrent kidney stones (calcium oxalate calculi) in males with a urinary uric acid level of more than 800 mg/day, or in females with levels greater than 750 mg/day. Keep it in your carry-on bag. Starting with a low dose of allopurinol and febuxostat is strongly recommended over starting at a higher dose. The more common side effects of febuxostat can include: If these effects are mild, they may go away within a few days or a couple of weeks. Store febuxostat at room temperature between 59°F and 86°F (15°C and 30°C). Rarely, may cause reversible liver damage or elevations in liver enzymes. A newer drug, febuxostat (Uloric), is similar to allopurinol in the way it works. It should not be used in children younger than 18 years. May cause a skin rash which may be a sign of an allergic reaction to allopurinol. A fluid intake of 2 liters per day is recommended to reduce the risk of kidney stones developing. If you forget a dose of allopurinol, you do not need to double up the next dose. Can Different Parts of the Celery Plant Naturally Treat Gout? Always carry the original prescription-labeled container with you. They can’t harm your medication. 14,10 Half-life. The second is if you have tried allopurinol and it was not effective enough for you. Gout treatments try to reduce the pain of individual gout attacks, and the frequency of attacks. Studies suggest that vitamin C may…, Research has shown that certain compounds in celery seed may have benefits in treating gout. Allopurinol, taken as a pill. Febuxostat decreases uric acid levels by blocking xanthine oxidase. We look at bifocal contacts from dailies to longer wears and answer some of the most asked questions when it comes to multifocal contacts. Febuxostat oral tablet doesn’t typically cause drowsiness. The major metabolites of caffeine can be found excreted in the urine. Always carry your medication with you. Learn the symptoms, what causes it, and how it's…, Hyperuricemia, a condition where there is too much uric acid in your body, is considered to be the cause of gout. Allopurinol belongs to the class of medicines called xanthine oxidase inhibitors. Always discuss possible side effects with a healthcare provider who knows your medical history. It’s not available as a generic drug. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. You should always consult your doctor or other healthcare professional before taking any medication. Your goal is a uric acid level in your blood that is less than 6 mg/dL. Doing so can cause dangerous effects in your body. If you think you’ve taken too much of this drug, call your doctor or local poison control center. Febuxostat comes only as a tablet you take by mouth. To help avoid interactions, your doctor should manage all of your medications carefully. But if you remember just a few hours before your next scheduled dose, take only one dose. Talk to your doctor about other drug options that may work for you. Ensure you maintain a good intake of fluid while taking allopurinol. For people with severe kidney disease: Your maximum dosage should be 40 mg once per day. Levels of a substance called xanthine could build up in your urine and cause stones in your urinary tract. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Last updated on March 20, 2020. May be used temporarily to reduce elevated uric acid levels caused by certain cancer treatments in people with leukemia, lymphoma, and other malignancies. Allopurinol is a maintenance treatment for gout or high uric acid levels so it should be taken regularly even once a gout attack has resolved. If you stop taking the drug suddenly or don’t take it at all: Your uric acid levels will likely remain high and continue to cause gout symptoms. This drug has a boxed warning. discomfort in the upper right part of your abdomen, weakness or numbness in one part or side of your body, trouble seeing in one or both of your eyes. It may take two to six weeks before allopurinol effectively reduces gout attacks. If your symptoms are severe, call 911 or your local emergency services or go to the nearest emergency room right away. A prescription for this medication is refillable. This information is not a substitute for medical advice. Important information about gout medication Allopurinol may be taken once daily. It's tied to gout. It’s used for people who are unable to take allopurinol, or who have tried allopurinol and it was not effective enough for them. Talk to your doctor if you breastfeed your child. If you have a history of cardiovascular disease, you should only use febuxostat to treat your gout in two situations. People with kidney disease who are receiving thiazide diuretics in addition to allopurinol are considered at higher risk. Febuxostat oral tablet is used to treat hyperuricemia (constantly high levels of uric acid) in adults who have gout. While the virus can be present on these items, taking preventative steps can reduce…. It comes with serious risks if you don’t take it as prescribed. For people with severe kidney disease: If you have severe kidney disease, talk to your doctor about whether this drug is right for you. Don’t put this medication in your car’s glove compartment or leave it in the car. Both of these things can help make febuxostat work better for you. Febuxostat oral tablet is used to treat hyperuricemia (constantly high levels of uric acid) in adults who have gout. In people with severe kidney disease, a dosage of 100 mg/day or 300mg twice a week may be sufficient to reduce high uric acid levels. Available as an oral tablet and as an injection. Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. This can help make sure you stay safe during your treatment. If you miss doses or don’t take the drug on schedule: Your medication may not work as well or may stop working completely. An interaction is when a substance changes the way a drug works. Uric acid levels. A class of drugs is a group of medications that work in a similar way. Febuxostat oral tablet is used for long-term treatment. Your doctor may check your levels of uric acid two weeks after starting febuxostat. It can take several months before you notice its effect. You’ll usually keep taking these with your allopurinol for at least the first three months. You may need to show airport staff the pharmacy label for your medication. You should not need a new prescription for this medication to be refilled. The first is if you’re not able to take the gout drug allopurinol. Febuxostat also may increase the risk of heart-related death. If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include: Note: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. For people with other causes of high uric acid levels: If you have high uric acid levels associated with cancer or cancer treatments or with Lesch-Nyhan syndrome, this drug may not be a good option for you. However, it can cause other side effects. Febuxostat side effects include rash, nausea and reduced liver function. The need for continued treatment should be reassessed periodically. The cost of these tests will depend on your insurance coverage. Occasionally may cause drowsiness. Allopurinol or febuxostat is strongly recommended over probenecid as a first-line treatment for patients with moderate-to-severe chronic kidney disease. It’s not available as a generic drug. Febuxostat may cause a severe allergic reaction. Discontinue allopurinol at the first appearance of a skin rash, painful urination, blood in the urine, eye irritation, or facial swelling and seek urgent medical advice. Debra Sullivan, Ph.D., MSN, R.N., CNE, COI. Allopurinol may be better tolerated if taken with food. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist. This means your doctor may need to get approval from your insurance company before your insurance company will pay for the prescription. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. Disclaimer: Our goal is to provide you with the most relevant and current information. Symptoms of gout include pain, swelling, redness, heat, soreness, and stiffness in certain joints. Allopurinol reduces levels of uric acid in the blood and the urine. You can take febuxostat with or without food. All rights reserved. In head-to-head trials, febuxostat looked to be more effective than allopurinol at controlling uric acid levels, although that was likely because the allopurinol dose in the study was too low. If febuxostat isn't suitable for you, your doctor may suggest you take other medicines, such as sulfinpyrazone and benzbromarone. There are other drugs available to treat your condition. Febuxostat oral tablet may be used as part of a combination therapy. ACE inhibitors, such as benazepril, captopril, or fosinopril, antacids, such as those containing aluminum, antiviral medications, such as didanosine or entecavir, chemotherapy treatments, such as cyclophosphamide or mercaptopurine. Allopurinol. It helps decrease your symptoms of gout. Peak levels of allopurinol are reached within 1.5 hours and 4.5 hours for its active metabolite. You should also drink plenty of water. Don’t worry about airport X-ray machines. The use of pegloticase is strongly recommended against as a first-line treatment. For women who are breastfeeding: Febuxostat may pass into breast milk and cause side effects in a child who is breastfed. Not every pharmacy stocks this drug. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Febuxostat belongs to a class of drugs called xanthine oxidase inhibitors. This is the most serious warning from the Food and Drug Administration (FDA). Always speak with your doctor or pharmacist about dosages that are right for you. If you develop liver damage while taking this drug and a cause can’t be determined, your doctor may stop your use of this drug. Affected people should not drive or operate machinery. If you take too much: You could have dangerous levels of the drug in your body. Side effects of allopurinol include fever, rash, hepatitis and kidney problems. These substances may be in some of the foods you eat. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. Febuxostat oral tablet is available as a brand-name drug. You and your doctor will decide whether breastfeeding is safe. Just continue taking allopurinol as scheduled. Prevention Can I prevent gout? Allopurinol may be used to decrease levels of uric acid in people with gout, kidney stones, or who are receiving certain types of chemotherapy. Available for Android and iOS devices. You should refer to the prescribing information for allopurinol for a complete list of interactions. Rarely, may cause bone marrow depression. Our website services, content, and products are for informational purposes only. Take this drug at the time(s) recommended by your doctor. May also cause diarrhea, nausea, and laboratory test changes. How to tell if the drug is working: Your uric acid levels should decrease after about 2 weeks of taking febuxostat. Just continue taking allopurinol as scheduled. Adjusting your diet is the most important way to…, A gout flare can be controlled with short-term and long-term medications. You can make certain lifestyle changes to help prevent gout: Drink plenty of water to help your kidneys function better and avoid dehydration. Don’t take this drug again if you’ve ever had an allergic reaction to it. If you become pregnant while taking this drug, call your doctor right away. 1,7-Dimethyluric acid; Route of elimination. Hyperuricemia happens if there's too much uric acid in your blood. Coadministration with colchicine or an anti-inflammatory agent is recommended initially, in addition to gradually increasing the dosage of allopurinol. Allopurinol (Aloprim, Lopurin, ... treats chronic gout by lowering the uric acid produced in your body. May occur anywhere from 6 weeks to years after administration of allopurinol and the risk is greatest in those receiving other drugs that also have the potential to cause bone marrow depression. High levels of uric acid in your blood can cause gout. Taking febuxostat places you at a much greater risk of cardiovascular death than taking allopurinol.
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